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Transmission electron microscopy (TEM) (Figure 2) and atomic force microscopy (AFM) assess particle size and morphology (110 nm), while X-ray diffraction (XRD) reveals partial graphitisation with broad peaks near 24 [26, 34]

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Serious adverse events were uncommon in these trials, but rare outcomes and longer-term cardiovascular, renal, or oncologic risks require ongoing surveillance beyond trial lengths